Best way to remove dog urine odor?

I am buying a foreclosed home that apparently was sabotaged by the former owner before he/she left. It appears more than one large dogs were left in the vacant house, unattended, for an extended period. The stench hits you like a wall when you enter the house. Additionally, it appears every carpet in the home was intentionally stained with paint and stain. All the flooring in the house will be replaced.

My concern is that not all of the smell will be eliminated by replacement of the flooring. Is there some reliable method for treating the subfloors to neutralize the urine and kill the odor?

Bump. No help from anyone?

A few years ago I repaired a rental trailer for a sister in law. The renters had knocked holes in the walls and floors and let there dogs and pet ferrets run loose through the house. The place smelled like a sewer pit! I removed all of the floor coverings and rented a spray rig from a local home center and sprayed a product called "KILLS" over every exposed surface. Two years latter there was still no smell. So it seemed to work.
Good Luck.

Are you referring to "Kilz"? It is a polyeurathane based primer that is intended to cover water stains and paint colors and seal them, so that they don't bleed through the top-coat paint. I have been told elsewhere that it will work for the urine. I think I'm going to do exactly what you did. I'm going to rip out all the flooring, right down to the subfloor, tape all the windows and doors, and spray the floors and walls with at least two coats of Kilz. We'll see how it works.

Thanks for your input.

Generally speaking the proteins in the urine are what cause the unikely dog smelling uring, before you Kilz everything, you might want to get some enzyme based cleaner from Petsmart (or wherever) that is designed to break down the 'stinky' proteins. doesn't do anything for the stain, but it got that (especially unfixed male dog) smell out. I've had Kilz fail to Kill smell before, which is why I tried this stuff. Worked great, then I Kilzed the stain itself...

Thanks for the info. That is exactly what we are doing. Ripped out all the carpet last week and found the subfloor in some areas to be beyond hope. I have been told the former owner may have had as many as 30 dogs living in the house as a kennel before the bank foreclosed. It is pretty bad. We are spraying with a product from Walmart, can't think of the brand name right now, but it is formulated to neutralize dog urine and kill the smell. It seems to be working. We are applying it with a garden pressure sprayer (the kind you use for herbicide/insecticide), lightly wetting the subfloors, allowing it to dry between applications. A couple sections of subfloor, as I said before, will need to be replaced, due to the quantity of urine in those areas having damaged the wood. However, we are confident we will be able to kill all the odor with a combination of the enzymatic mixture we are applying and the Kilz.

I hope this thread will be helpful to others who may encounter this problem. My case is the worst I have come across. If we can fix this one, anything less should be a snap.